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SNX5

From Wikipedia, the free encyclopedia
SNX5
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesSNX5, sorting nexin 5
External IDsOMIM: 605937; MGI: 1916428; HomoloGene: 40944; GeneCards: SNX5; OMA:SNX5 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_152227
NM_001282454
NM_014426

NM_001199188
NM_024225

RefSeq (protein)

NP_001269383
NP_055241
NP_689413

NP_001186117
NP_077187

Location (UCSC)Chr 20: 17.94 – 17.97 MbChr 2: 144.09 – 144.11 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Sorting nexin-5 is a protein that in humans is encoded by the SNX5 gene.[5][6][7]

This gene encodes a member of the sorting nexin family. Members of this family contain a phox (PX) domain, which is a phosphoinositide binding domain, and are involved in intracellular trafficking. This protein is a component of the mammalian retromer complex,[6] which facilitates cargo retrieval from endosomes to the trans-Golgi network. It has also been shown to bind to the Fanconi anemia, complementation group A protein. This gene results in two transcript variants encoding the same protein.[7]

Interactions

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SNX5 has been shown to interact with FANCA.[5]

References

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000089006Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000027423Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ a b Otsuki T; Kajigaya S; Ozawa K; Liu JM (Jan 2000). "SNX5, a new member of the sorting nexin family, binds to the Fanconi anemia complementation group A protein". Biochem Biophys Res Commun. 265 (3): 630–5. doi:10.1006/bbrc.1999.1731. PMID 10600472.
  6. ^ a b Wassmer T; Attar N; Bujny MV; Oakley J; Traer CJ; Cullen PJ (Dec 2006). "A loss-of-function screen reveals SNX5 and SNX6 as potential components of the mammalian retromer". J Cell Sci. 120 (Pt 1): 45–54. doi:10.1242/jcs.03302. PMID 17148574.
  7. ^ a b "Entrez Gene: SNX5 sorting nexin 5".

Further reading

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