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HOXB4

From Wikipedia, the free encyclopedia
HOXB4
Identifiers
AliasesHOXB4, HOX-2.6, HOX2, HOX2F, homeobox B4
External IDsOMIM: 142965; MGI: 96185; HomoloGene: 32095; GeneCards: HOXB4; OMA:HOXB4 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_024015

NM_010459

RefSeq (protein)

NP_076920

NP_034589

Location (UCSC)Chr 17: 48.58 – 48.58 MbChr 11: 96.21 – 96.21 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Homeobox protein Hox-B4 is a protein that in humans is encoded by the HOXB4 gene.[5][6][7]

Function

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This gene is a member of the Antp homeobox family and encodes a nuclear protein with a homeobox DNA-binding domain. It is included in a cluster of homeobox B genes located on chromosome 17. The encoded protein functions as a sequence-specific transcription factor that is involved in development. Intracellular or ectopic expression of this protein expands hematopoietic stem and progenitor cells in vivo and in vitro, making it a potential candidate for therapeutic stem cell expansion.[7]

See also

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References

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000182742Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000038692Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ McAlpine PJ, Shows TB (Jul 1990). "Nomenclature for human homeobox genes". Genomics. 7 (3): 460. doi:10.1016/0888-7543(90)90186-X. PMID 1973146.
  6. ^ Scott MP (Nov 1992). "Vertebrate homeobox gene nomenclature". Cell. 71 (4): 551–3. doi:10.1016/0092-8674(92)90588-4. PMID 1358459. S2CID 13370372.
  7. ^ a b "Entrez Gene: HOXB4 homeobox B4".

Further reading

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This article incorporates text from the United States National Library of Medicine, which is in the public domain.