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NFATC4

From Wikipedia, the free encyclopedia
NFATC4
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesNFATC4, NF-AT3, NF-ATC4, NFAT3, nuclear factor of activated T-cells 4, nuclear factor of activated T cells 4
External IDsOMIM: 602699; MGI: 1920431; HomoloGene: 3349; GeneCards: NFATC4; OMA:NFATC4 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001168346
NM_023699

RefSeq (protein)

NP_001161818
NP_076188

Location (UCSC)Chr 14: 24.37 – 24.38 MbChr 14: 56.06 – 56.07 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Nuclear factor of activated T-cells, cytoplasmic 4 is a protein that in humans is encoded by the NFATC4 gene.[5][6]

Function

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The product of this gene is a member of the nuclear factors of activated T cells DNA-binding transcription complex. This complex consists of at least two components: a preexisting cytosolic component that translocates to the nucleus upon T cell receptor (TCR) stimulation and an inducible nuclear component. Other members of this family of nuclear factors of activated T cells also participate in the formation of this complex. The product of this gene plays a role in the inducible expression of cytokine genes in T cells, especially in the induction of the IL-2 and IL-4.[6]

Interactions

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NFATC4 has been shown to interact with CREB-binding protein.[7]

See also

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References

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  1. ^ a b c ENSG00000285485 GRCh38: Ensembl release 89: ENSG00000100968, ENSG00000285485Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000023411Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Hoey T, Sun YL, Williamson K, Xu X (May 1995). "Isolation of two new members of the NF-AT gene family and functional characterization of the NF-AT proteins". Immunity. 2 (5): 461–72. doi:10.1016/1074-7613(95)90027-6. PMID 7749981.
  6. ^ a b "Entrez Gene: NFATC4 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 4".
  7. ^ Yang T, Davis RJ, Chow CW (Oct 2001). "Requirement of two NFATc4 transactivation domains for CBP potentiation". The Journal of Biological Chemistry. 276 (43): 39569–76. doi:10.1074/jbc.M102961200. PMID 11514544.

Further reading

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This article incorporates text from the United States National Library of Medicine, which is in the public domain.