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V-erbA-related gene

From Wikipedia, the free encyclopedia

NR2F6
Identifiers
AliasesNR2F6, EAR-2, EAR2, ERBAL2, nuclear receptor subfamily 2 group F member 6
External IDsOMIM: 132880; MGI: 1352453; HomoloGene: 7706; GeneCards: NR2F6; OMA:NR2F6 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_005234

NM_010150

RefSeq (protein)

NP_005225
NP_005225.2

NP_034280

Location (UCSC)Chr 19: 17.23 – 17.25 MbChr 8: 71.83 – 71.83 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

V-erbA-related protein 2 (EAR-2) also known as NR2F6 (nuclear receptor subfamily 2 group F member 6) is a protein that in humans is encoded by the NR2F6 gene.[5] V-erbA-related protein 2 is a member of the nuclear receptor family of intracellular transcription factors. It is named after its similarity to v-erbA (P03373), a helper of an oncoprotein called v-erbB in avian erythroblastosis virus.[6]

Function

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Comparatively little is known about ear-2, but it has been shown to function as a coregulator of other nuclear receptors.[7][8]

Interactions

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V-erbA-related gene has been shown to interact with:

References

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000160113Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000002393Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Miyajima N, Kadowaki Y, Fukushige S, Shimizu S, Semba K, Yamanashi Y, et al. (December 1988). "Identification of two novel members of erbA superfamily by molecular cloning: the gene products of the two are highly related to each other". Nucleic Acids Research. 16 (23): 11057–74. doi:10.1093/nar/16.23.11057. PMC 338996. PMID 2905047.
  6. ^ Thormeyer D, Baniahmad A (October 1999). "The v-erbA oncogene (review)". International Journal of Molecular Medicine. 4 (4): 351–358. PMID 10493974.
  7. ^ a b Zhu XG, Park KS, Kaneshige M, Bhat MK, Zhu Q, Mariash CN, et al. (April 2000). "The orphan nuclear receptor Ear-2 is a negative coregulator for thyroid hormone nuclear receptor function". Molecular and Cellular Biology. 20 (7): 2604–18. doi:10.1128/MCB.20.7.2604-2618.2000. PMC 85476. PMID 10713182.
  8. ^ Liu X, Huang X, Sigmund CD (May 2003). "Identification of a nuclear orphan receptor (Ear2) as a negative regulator of renin gene transcription". Circulation Research. 92 (9): 1033–40. doi:10.1161/01.RES.0000071355.82009.43. PMID 12690040.
  9. ^ Avram D, Ishmael JE, Nevrivy DJ, Peterson VJ, Lee SH, Dowell P, et al. (May 1999). "Heterodimeric interactions between chicken ovalbumin upstream promoter-transcription factor family members ARP1 and ear2". The Journal of Biological Chemistry. 274 (20): 14331–6. doi:10.1074/jbc.274.20.14331. PMC 2823254. PMID 10318855.

Further reading

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