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KLF12

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KLF12
Identifiers
AliasesKLF12, AP-2rep, AP2REP, HSPC122, Kruppel-like factor 12, Kruppel like factor 12
External IDsOMIM: 607531; MGI: 1333796; HomoloGene: 21417; GeneCards: KLF12; OMA:KLF12 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_007249
NM_016285

NM_010636

RefSeq (protein)

NP_009180

NP_034766

Location (UCSC)Chr 13: 73.69 – 74.13 MbChr 14: 99.87 – 100.28 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Krueppel-like factor 12 is a protein that in humans is encoded by the KLF12 gene.[5][6]

Activator protein-2 alpha (AP-2 alpha) is a developmentally-regulated transcription factor and important regulator of gene expression during vertebrate development and carcinogenesis. The protein encoded by this gene is a member of the Kruppel-like zinc finger protein family and can repress expression of the AP-2 alpha gene by binding to a specific site in the AP-2 alpha gene promoter. Repression by the encoded protein requires binding with a corepressor, CtBP1. Two transcript variants encoding different isoforms have been found for this gene.[6]

See also

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References

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000118922Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000072294Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Roth C, Schuierer M, Gunther K, Buettner R (Jul 2000). "Genomic structure and DNA binding properties of the human zinc finger transcriptional repressor AP-2rep (KLF12)". Genomics. 63 (3): 384–90. doi:10.1006/geno.1999.6084. PMID 10704285.
  6. ^ a b "Entrez Gene: KLF12 Kruppel-like factor 12".

Further reading

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This article incorporates text from the United States National Library of Medicine, which is in the public domain.